Thioredoxin Reductase and its Inhibitors

Author(s): Fulvio Saccoccia, Francesco Angelucci, Giovanna Boumis, Daniela Carotti, Gianni Desiato, Adriana E. Miele and Andrea BellelliPages 621-646 (26) Abstract: Thioredoxin plays a crucial role in a wide number of physiological processes, which span from reduction of nucleotides to deoxyriboucleotides...

Read More

Disintegrins from Snake Venoms and their Applications in Cancer Research and Therapy

Author(s): Jessica Kele Arruda Macedo, Jay W. Fox and Mariana de Souza CastroPages 532-548 (17) Abstract: Integrins regulate diverse functions in cancer pathology and in tumor cell development and contribute to important processes such as cell shape, survival, proliferation, transcription, angiogenesis,...

Read More

Targeting EZH2 for Cancer Therapy: Progress and Perspective

Author(s): Chi Han Li and Yangchao ChenPages 559-570 (12) Abstract: Enhancer of Zeste Homolog 2 (EZH2) is the core component of the polycomb repressive complex 2 (PRC2), possessing the enzymatic activity in generating di/tri-methylated lysine 27 in histone H3. EZH2 has important roles during...

Read More

Mutations of Chromatin Structure Regulating Genes in Human Malignancies

Author(s): Jian Chen, Franklin H. Herlong, John R. Stroehlein and Lopa MishraPages 411-437 (27) Abstract: Chromatin structure regulating processes mediated by the adenosine triphosphate (ATP) – dependent chromatin remodeling complex and the covalent histone-modifying complexes are critical to...

Read More

The Melanocortin Receptor System: A Target for Multiple Degenerative Diseases

Author(s): Minying Cai and Victor J. HrubyPages 488-496 (9) Abstract: The melanocortin receptor system consists of five closely related G-protein coupled receptors (MC1R, MC2R, MC3R, MC4R and MC5R). These receptors are involved in many of the key biological functions for multicellular animals,...

Read More